The Seattle Mariners (77-59) and Cincinnati Reds (71-68) open a 3-game set Monday at Great American Ball Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Mariners vs. Reds </strong odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting since Mariners won 2 of 3 games at home in 2019

The Mariners lost 6-3 as -146 favorites at the New York Mets Sunday. Seattle has won 6 of its last 9 games and is in 1st place in the AL West with a 1-game lead over the Texas Rangers and Houston Astros.

The Reds lost 15-7 as +129 home underdogs vs. the Chicago Cubs Sunday. Cincinnati fell to 3 games behind 2nd-place Chicago in the NL Central and is in a tight race with the Arizona Diamondbacks Miami Marlins and San Francisco Giants for the final Wild Card spot.

Mariners at Reds projected starters

RHP Bryan Woo vs. RHP Tejay Antone

Woo (2-3 4.15 ERA) makes his 14th start. The rookie has a 1.17 WHIP 2.6 BB/9 and 9.4 K/9 in 65 innings.

• Last start: Win 6 IP 0 ER 3 H 1 BB 5 K in 7-0 home victory vs. Oakland Athletics last Monday
• 2023 road stats: 1-1 3.92 ERA (39 IP 17 ER) in 8 starts
• Never faced Reds before

Antone (0-0 0.00 ERA) makes his 1st start and 2nd appearance. He pitched 1 scoreless inning in his season debut vs. the Cubs Saturday giving up 1 H and 0 BB with 1 K in relief.

• Spent most of the 2023 season recovering from Tommy John surgery
• Went 2-0 with a 2.14 ERA 0.89 WHIP 3.5 BB/9 and 11.2 K/9 in 33 2/3 IP across 23 relief appearances in 2021

Mariners at Reds odds

Provided by BetMGM SportsbookUSA TODAY Sports Scores and Sports Betting Odds hub Lines last updated at 10:56 a.m. ET.

• Moneyline (ML): Mariners -165 (bet $165 to win $100) | Reds +140 (bet $100 to win $140)
• Run line (RL)/Against the spread (ATS): Mariners -1.5 (-110) | Reds +1.5 (-110)
• Over/Under (O/U): 10.5 (O: -105 | U: -115)

Mariners at Reds picks and predictions

Prediction

Mariners 6 Reds 3

Moneyline

Seattle (-165) should bounce back after losing 2 of 3 games at the New York Mets over the weekend but there’s no need to pay the higher price on the moneyline when the Mariners should win by multiple runs.

PASS. Bet the run line and/or the total instead.

Run line/Against the spread

Twelve of Seattle’s last 17 wins have been by multiple runs and Cincinnati’s last 5 losses have been by 2 or more runs. Antone is expected to make just his 2nd appearance after spending 2 years on the IL and I like the Mariners’ chances of getting to him early before running up the score vs. the Reds’ bullpen.

BET MARINERS -1.5 (-110).

Over/Under

The Under is 40-27 (59.7%) in Reds games this season when they’re coming off a loss according to TeamRankings.com.

The Under is also 22-17-1 (56.4%) this year when the Mariners face NL opponents. With a total this high and the Reds’ offensive struggles as of late I’m looking to play UNDER 10.5</strong (-115).