Chelsea, and all their new signings, kick the weekend off on Friday with a west London derby at home to Fulham. The pressure will be on head coach Graham Potter more than ever to deliver results after the club single-handedly spent more than any other league on players last month. Four of the bottom six clubs are on the road, as they fight for their Premier League survival. 

Here are our best Premier League bets for Matchday 22 (odds via DraftKings Sportsbook, FanDuel Sportsbook, and Caesars).

Matchday 22 Premier League Schedule and Odds

(Odds via FanDuel)

Chelsea (-165) vs. Fulham (+470)

Everton (+700) vs. Arsenal (-240)

Wolves (+310) vs. Liverpool (-115)

Manchester United (-270) vs. Crystal Palace (+750)

Newcastle (-160) vs. West Ham (+490)

Tottenham (+340) vs. Manchester City (-140)