NFL Week 13 Odds: Patriots vs Bills Betting Analysis & Prediction


Scorching New England looks to take an outright lead over AFC East rival Buffalo in one of the season’s best Monday night matchups. The Patriots are the hottest team in the league, but still haven’t wrested first place in the AFC East away from the Bills. Will Josh Allen and his teammates grab the victory and cover? Or will the Pats continue dominating their opponents? Check out NFL odds, analysis, and a free pick for New England at Buffalo. 

NFL Betting Preview for New England Patriots at Buffalo

New England Patriots vs Buffalo Bills Game Odds & Info | NFL Week 13 Betting

  • When: Monday, Dec. 6 at 8:15 pm ET
  • Where: Highmark Stadium, Orchard Park, NY
  • TV / Streaming: ESPN / ESPN+ 
  • ATS Odds: Buffalo -3 
  • Moneyline Odds: New England +130 / Buffalo -150     
  • Over/Under Odds: 44    

Why bet on New England versus Buffalo?

On Monday, New England goes for their seventh straight victory. The Patriots not only have won six straight, but they’ve covered in all six. Not only that, but with each subsequent win, the Patriots get stronger. On Nov. 18, New England beat Atlanta 25-10. Then on Nov. 28, the Patriots dusted then playoff 1-seed Tennessee 36-13.   

New England Patriots Offensive Averages

  • Total Yards: 355.3
  • Passing Yards: 240.0
  • Rushing Yards: 115.3
  • Points Scored: 28.0
  • Turnovers: 15

New England Patriots Defensive Averages

  • Total Yards: 316.7
  • Passing Yards: 200.9
  • Rushing Yards: 115.8
  • Points Scored: 15.8
  • Takeaways: 25

Why bet on Buffalo versus New England?

Buffalo hadn’t looked good in 2-of-3 games. But a trip to New Orleans on Thanksgiving night left no doubt that the Bills remain one of the top contenders to win the Super Bowl. Versus the Saints, Buffalo dominated. Josh Allen threw 4 TD passes and the Bills held New Orleans to just 6 points in the 31-6 victory. Now back on track, Buffalo may not look back on their way to an AFC title. 

Buffalo Bills Offensive Averages

  • Total Yards: 389.3
  • Passing Yards: 271.0
  • Rushing Yards: 119.3
  • Points Scored: 29.6
  • Turnovers: 16

Buffalo Bills Defensive Averages

  • Total Yards: 275.2
  • Passing Yards: 178.5
  • Rushing Yards: 96.6
  • Points Scored: 16.5
  • Takeaways: 23

New England versus Buffalo Relevant Trends

  • Patriots are 6-0 ATS in their last 6
  • New England is 5-0 ATS in their last 5 following a straight up win
  • Over is 4-0 in the Patriots’ last 4 versus a team with a winning record
  • Bills are 1-3-1 ATS in their last 5 versus the AFC
  • Buffalo is 3-14 ATS in the last 17 meetings at home
  • Over is 4-1 in the Bills’ last 5 following an ATS win 

New England Patriots at Buffalo Bills Final Betting Prediction

The Bills looked good beating New Orleans. However, after NFL Week 13 Thursday’s game versus the Cowboys, the Saints have now lost six straight.

New Orleans isn’t a good football team. So we can’t look at Buffalo’s victory over the Saints to give us clues as to how the Bills will perform against the New England Patriots.

Right now, Bill Belichick’s team is the best in the NFL. Rookie quarterback Mac Jones has an 11-to-3 TD to INT ratio during the six game winning streak. Jones completes over 70% of his passes.

Not only that, but New England’s defense ranks first in points allowed per game. Buffalo also has a good defense. But the Bills must play this one without Tre’Davious White.

Their best cornerback is out for the season with a knee injury. Any way we look at it, the Patriots prevail. New England moneyline is the play. 

NFL Week 13 Pick: New England Patriots moneyline 


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