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Our NFL computer picks are unbiased, entirely data-driven NFL predictions using machine-learning techniques as inputs to a Monte Carlo approach. That means we simulate an NFL game more than 10,000 times, considering the full range of outcomes and probabilities.
Check out all of our Week 1 NFL Computer Picks Against The Spread, the Over/Under Points Totals, and our score projections for every game this weekend, below.
Carolina Panthers vs Atlanta Falcons Computer Picks & Score Predictions
Score Projection: Panthers 22 Falcons 21
ATS Prediction: Panthers +3.5
O/U Prediction: Over 39.5 points
Tampa Bay Buccaneers vs Minnesota Vikings Computer Picks & Score Predictions
Score Projection: Buccaneers 21 Vikings 24
ATS Prediction: Buccaneers +6
O/U Prediction: Under 45.5 points
Cincinnati Bengals vs Cleveland Browns Computer Picks & Score Predictions
Score Projection: Bengals 26 Browns 19
ATS Prediction: Bengals -2.5
O/U Prediction: Under 48.5 points
Jacksonville Jaguars vs Indianapolis Colts Computer Picks & Score Predictions
Score Projection: Jaguars 24 Colts 20
ATS Prediction: Colts +5
O/U Prediction: Under 45.5 points
San Francisco 49ers vs Pittsburgh Steelers Computer Picks & Score Predictions
Score Projection: 49ers 26 Steelers 20
ATS Prediction: 49ers -2.5
O/U Prediction: Over 41 points
Tennessee Titans vs New Orleans Saints Computer Picks & Score Predictions
Score Projection: Titans 20 Saints 21
ATS Prediction: Titans +3
O/U Prediction: Over 41 points
Arizona Cardinals vs Washington Commanders Computer Picks & Score Predictions
Score Projection: Cardinals 21 Commanders 22
ATS Prediction: Cardinals +7
O/U Prediction: Over 38 points
Houston Texans vs Baltimore Ravens Computer Picks & Score Predictions
Score Projection: Texans 18 Ravens 26
ATS Prediction: Texans +10
O/U Prediction: Over 43.5 points
Philadelphia Eagles vs New England Patriots Computer Picks & Score Predictions
Score Projection: Eagles 25 Patriots 20
ATS Prediction: Eagles -4
O/U Prediction: Over 45 points
Las Vegas Raiders vs Denver Broncos Computer Picks & Score Predictions
Score Projection: Raiders 25 Broncos 22
ATS Prediction: Raiders +3.5
O/U Prediction: Over 44 points
Miami Dolphins vs Los Angeles Chargers Computer Picks & Score Predictions
Score Projection: Dolphins 22 Chargers 23
ATS Prediction: Dolphins +3
O/U Prediction: Under 51 points
Los Angeles Rams vs Seattle Seahawks Computer Picks & Score Predictions
Score Projection: Rams 23 Seahawks 23
ATS Prediction: Rams +5
O/U Prediction: Under 46.5 points
Green Bay Packers vs Chicago Bears Computer Picks & Score Predictions
Score Projection: Packers 26 Bears 17
ATS Prediction: Packers +1
O/U Prediction: Over 42 points
Dallas Cowboys vs New York Giants Computer Picks & Score Predictions
Score Projection: Cowboys 26 Giants 20
ATS Prediction: Cowboys -3.5
O/U Prediction: Over 46 points
Buffalo Bills vs New York Jets Computer Picks & Score Predictions
Score Projection: Bills 29 Jets 16
ATS Prediction: Bills -2.5
O/U Prediction: Under 45.5 points