Week 12 of the 2024 NFL regular season is on the immediate horizon and it will begin with Thursday Night Football between the AFC North rival Pittsburgh Steelers and Cleveland Browns. Sunday’s slate isn’t especially appealing on paper, but a matchup featuring the San Francisco 49ers and Green Bay Packers could be worth watching, with the Niners in particular desperate for a victory after falling to 5-5 yesterday afternoon. The week wraps up with the Los Angeles Chargers hosting the Baltimore Ravens on Monday Night Football.  

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also, make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 12 opening lines and give our best early bet to make.

NFL Week 12 opening lines and odds 

Odds available at DraftKings Sportsbook at time of publishing 

• Pittsburgh Steelers -4.5 (-108) vs Cleveland Browns +4.5 (-112) – Thursday Night Football 
• Detroit Lions -8 (-110) vs Indianapolis Colts +8 (-110)
• Tampa Bay Buccaneers -4 (-110) vs New York Giants +4 (-110)  
• Minnesota Vikings -3.5 (-112) vs Chicago Bears +3.5 (-108)
• New England Patriots +7.5 (-110) vs Miami Dolphins -7.5 (-110)
• Dallas Cowboys +10 (-110) vs Washington Commanders -10 (-110)
• Kansas City Chiefs -11.5 (-110) vs Carolina Panthers +11.5 (-110)  
• Tennessee Titans +7.5 (-110) vs Houston Texans -7.5 (-110)
• Denver Broncos -4.5 (-110) vs Las Vegas Raiders +4.5 (-110)
• San Francisco 49ers +1 (-110) vs Green Bay Packers -1 (-110)
• Arizona Cardinals +1 (-110) vs Seattle Seahawks +1 (-110)
• Kansas City Chiefs +1.5 (-105) vs Buffalo Bills -1.5 (-115)
• Philadelphia Eagles -2.5 (-120) vs Los Angeles Rams +2.5 (+100) — Sunday Night Football 
• Baltimore Ravens -2 (-112) vs Los Angeles Chargers +2 (-108) — Monday Night Football

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Best bet for NFL Week 12: Pittsburgh Steelers -4.5 over Cleveland Browns (-108)

I generally don’t like giving more than a field goal in any AFC North matchup (those always seem to be close, hard-nosed contests), but an exception has to be made given the current directions of Pittsburgh and Cleveland. The Steelers are flying high at 8-2, while the Browns are in dire straits both this season (2-8) and as an overall franchise.

Will home-field advantage do anything to help? Probably not. Cleveland is 1-4 at Huntington Bank Field so far in 2024 and the fans don’t have any reason to get into it – not even against a division rival – with the season already over for all intents and purposes. Pittsburgh is 4-1 on the road, including a victory at the Washington Commanders during its current 5-game winning streak. Head coach Mike Tomlin’s team maintained momentum by earning a massive win over the Baltimore Ravens in Week 11. With both clubs playing on a short week, coaching will be a real factor – and right now I’ll side with Tomlin over pretty much anyone. Let’s get the party started early this week and make Thursday Night Football our early best bet. 

We’ll have NFL Week 12 picks for every game!