Week 3 of the NFL season is almost in the books. It has been an entertaining one, highlighted by Arizona’s upset of Dallas and Miami hanging a 70-spot on Denver. 

For now, though, it’s time to look ahead as opposed to behind. Most sportsbooks posted their numbers for the upcoming festivities on Sunday night, so it’s time to dissect the opening lines for Week 4. Make sure you keep checking our NFL predictions as we add our picks on the side and total for every game throughout the week. 

NFL Week 4 opening lines and odds 

Odds available at FanDuel Sportsbook at time of publishing. 

Detroit Lions -1 (-110) vs Green Bay Packers (-110) – Thursday Night Football
Atlanta Falcons +3 (-110) vs Jacksonville Jaguars (-110) – at Wembley Stadium, London
Miami Dolphins +2.5 (-102) vs Buffalo Bills (-118)
Baltimore Ravens +1.5 (-110) vs Cleveland Browns (-110)
Minnesota Vikings -3 (-110) vs Carolina Panthers (-110)
Tampa Bay Buccaneers +3 (-115) vs New Orleans Saints (-105)
Cincinnati Bengals +1.5 (-110) vs Tennessee Titans (-110)
Los Angeles Rams +1 (-110) vs Indianapolis Colts (-110)
Denver Broncos -2.5 (-115) vs Chicago Bears (-105)
Washington Commanders +7 (-110) vs Philadelphia Eagles (-110)
Pittsburgh Steelers -3 (-110) vs Houston Texans (-110)
Las Vegas Raiders +4 (-110) vs Los Angeles Chargers (-110)
New England Patriots +6.5 (-110) vs Dallas Cowboys (-110)
Arizona Cardinals +14.5 (-110) vs San Francisco 49ers (-110)
Kansas City Chiefs -9 (-110) vs New York Jets (-110) – Sunday Night Football
Seattle Seahawks -1.5 (-110) vs New York Giants (-110) – Monday Night Football 

Best early bets for NFL Week 4

Falcons +3 over Jaguars (-110)

The NFL is taking its talents to London for the first time this season, with the Falcons facing the Jaguars on Sunday at 9:30 am ET on ESPN+. Both teams looked horrible in Week 3, but Atlanta is still a solid 2-1 and Jacksonville is somewhat afloat at 1-2. This isn’t the worst matchup in the world for the International Series. I would take a field goal on either side for what has the makings of a close game.

Vikings -3 over Panthers (-110) 

Minnesota is stumbling into this contest at 0-3, but those 3 losses have come by a grand total of 13 points and all have come to opponents somewhere between decent and awesome (the Chargers, Buccaneers and Eagles). A matchup with Carolina should be just what the doctor ordered. The Panthers are also 0-3 and regardless of who is under center (Bryce Young or Andy Dalton) this team inspires zero confidence.

Chiefs -9 over Jets (-110)

Kansas City humiliated Chicago 41-10 in Week 3 and things could get out of hand again this coming Sunday with another bad opponent on the other side of the field. Zach Wilson has become a disaster in place of Aaron Rodgers and not even the Jets’ defense can be expected to contain a Chiefs offense that is rounding into form. I would get on this immediately before it balloons to – or over – the key number of 10.