Cleveland Guardians at Arizona Diamondbacks odds, picks and predictions


The Cleveland Guardians (32-37) continue their 6-game road trip against the NL West with the 2nd game of a 3-game series against the Arizona Diamondbacks (42-28).  First pitch is slated for Saturday at 10:10 p.m. ET (FS1) at Chase Field. Let’s analyze BetMGM Sportsbook’s lines around the Guardians vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 1-0.

The Guardians fell to 1-3 on their road trip and lost for the 4th time in 6 games allowing 11 hits in Arizona’s 5-1 series-opening win Friday.

RHP Zac Gallen pitched 7 innings of 1-run ball to lead the Diamondbacks to snap their 3-game losing streak. They are 7-3 in their last 10 games.

Guardians at Diamondbacks projected starters

RHP Shane Bieber vs. LHP Tommy Henry

Bieber (5-2 3.29 ERA) makes his 15th start. He has a 1.22 WHIP 2.4 BB/9 and 6.6 K/9 through 87 2/3 IP.

  • Last start: Win 7 IP 0 R 3 H 1 BB 9 K in 5-0 road win over Houston Astros on Sunday
  • Has allowed 2 or fewer runs in 8 starts this season

Henry (3-1 4.86 ERA) makes his 10th start and 11th appearance. He has a 1.38 WHIP 3.6 BB/9 and 5.9 K/9 through 50 IP.

  • Last start: No decision 4 2/3 IP 5 ER 9 H 1 BB 6 K in 9-8 home win over Philadelphia Phillies on Monday
  • ERA of 10.00 in 2 June starts after 2.87 ERA in 6 May appearances (5 starts)

Guardians at Diamondbacks odds

Provided by BetMGM SportsbookUSA TODAY Sports Scores and Sports Betting Odds hub Lines last updated at 11 a.m. ET.

  • Moneyline (ML): Guardians -115 (bet $115 to win $100) | Diamondbacks -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (+145) | Diamondbacks +1.5 (-175)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

Guardians at Diamondbacks picks and predictions


Diamondbacks 6 Guardians 4


The Diamondbacks are 22-17 at home and 7-3 in their last 10 games. The Guardians are 16-20 on the road.

The Diamondbacks are 7-2 when Henry pitches and 3-0 in his last 3.

The Guardians are 6-8 in Bieber’s starts but 3-1 in his last 4.

Arizona averages 7.2 runs per game in Henry’s starts.


Run line/Against the spread

Arizona is 42-28 ATS overall this season and 21-13 ATS as the underdogs.

Cleveland is 33-36 ATS overall but an abysmal 11-26 ATS when favored.

Betting Arizona to cover is the best bet here but it isn’t going to win you much money at -175 so taking slightly more risk on the outright win is worth it.



The Diamondbacks average 7.2 runs per game in Henry’s starts. Seven of his 9 starts have had at least 9 total runs.

Seven of Arizona’s last 11 games have had 9 or more total runs.

Five of Cleveland’s last 8 games have had 9 or more runs.

BET OVER 8.5 (-120).

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