The 2022 NFL trade deadline is fast approaching. Once the clock strikes 4 p.m. Eastern on Nov. 1, the Tuesday after Week 8, that's it. Historically, the biggest blockbusters are reserved for the offseason, but considering how much parity there is throughout the league six weeks into the year, there could be a bevy of teams working the phones to make or entertain offers.

Some clubs are poised to be buyers. Others are better positioned to sell. But here are 13 potential moves we like for both sides:

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49ers acquire: RB Christian McCaffrey
Panthers acquire: 2024 second-round pick, 2023 fourth-round pick, RB Tyrion Davis-Price

Kyle Shanahan can make most anyone thrive in his run-heavy system, but McCaffrey is of a different breed — so proven as a pass catcher that he'd give Jimmy Garoppolo (and/or Trey Lance down the road) an every-down safety valve, not to mention another Swiss Army Knife alongside Deebo Samuel. It wouldn't be an easy pill to swallow for Panthers fans, but Carolina's long-term needs are more important, and two picks plus a third-round rookie for a pricey, injury-prone RB is reasonable value.

Rams acquire: RB Melvin Gordon, 2023 sixth-round pick
Broncos acquire: RB Cam Akers

Gordon was briefly shunned for his fumbling issues in Denver, while Akers is already being shopped from L.A.'s nonexistent ground game. Why not swap outcast for outcast? Gordon would complement Darrell Henderson Jr., while Akers could instantly take over as the hurting Broncos' RB1, then share touches with Javonte Williams in 2023.

Bills acquire: RB Antonio Gibson
Commanders acquire: 2023 fourth-round pick

Rather than surrender multiple picks for McCaffrey, Buffalo could enhance its backfield by permitting Ron Rivera to make Brian Robinson Jr. the undisputed No. 1 in Washington. Gibson's skill set as a former hybrid wideout fits perfectly in an offense built to let Josh Allen air it out, and his arrival would take pressure off James Cook to be a play-making No. 2 for their playoff run.