The San Diego Padres (78-65) continue their road trip Thursday, kicking off a 4-game series against the Arizona Diamondbacks (67-75) for their final series against them this season. First pitch is 9:40 p.m. ET at Chase Field.

Season series: Padres lead 11-4

The Padres are coming off a 2-game series they split on the road against the Seattle Mariners. They have lost 3 of the last 4 games and 6 of their last 10. They hold a 2-game lead for the final AL wild-card spot.

The Diamondbacks salvaged 1 game in a 3-game series at home against the Los Angeles Dodgers, getting a 5-3 walk-off win in 10 innings Wednesday night. They have just 2 wins in their last 8 games.

Padres at Diamondbacks projected starters

LHP Sean Manaea vs. RHP Drey Jameson

Manaea  (7-8, 5.23 ERA) makes his 26th start in 27 appearances. He has a 1.36 WHIP, 3.0 BB/9 and 9.2 K/9 in 139 1/3 IP.

• Made a 1-inning appearance in relief 5 days ago, but in 2 previous starts has allowed 14 runs in 8 1/3 innings
• Is 2-0 with 2.88 ERA in 4 starts against Arizona

Jameson is making his major league debut. He was the Diamondbacks’ 1st-round selection in the 2019 draft.

Playing in both Double-A and Triple-A, he was 7-13 with a 6.31 ERA, 1.49 WHIP, 3.1 BB/9, 9.0 K/9 in 132 2/3 IP.

Padres at Diamondbacks odds

• Money line (ML): Padres -170 (bet $170 to win $100) | Diamondbacks +135 (bet $100 to win $135)
• Run line (RL)/Against the spread (ATS): Padres -1.5 (-105) | Diamondbacks +1.5 (-120)
• Over/Under (O/U): 8.5 (O: -135 | U: +110)

Padres at Diamondbacks picks and predictions

Prediction

Padres 5, Diamondbacks 3

Money line

The Diamondbacks simply struggle against the Padres and Los Angeles Dodgers. They have not won more than 1 game in any series against the Padres. Now they go up Manaea, who has pitched well against them in 4 outings. The Padres are 3-1 against Arizona when Manaea is on the mound.

It will be Jameson’s MLB debut, so there is no way to know what to expect from the young pitching prospect.

Take the PADRES (-170).

Run line/Against the spread

The Padres are 39-35 ATS on the road this season. Of their 11 wins over the Diamondbacks, 8 have been by at least 2 runs.

Eleven of the Diamondbacks’ last 12 losses have been by 2 or more runs.

Take the PADRES -1.5 (-105).

Over/Under

Thus far, 10 of the 15 games between the 2 teams have had 8 or fewer runs.

Four of the last 5 games and 8 of the last 13 for the Diamondbacks have had totals of 8 or fewer runs.

Take UNDER 8.5 (+110).

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