For the second time in less than a week, the New York Knicks (25-36) and Philadelphia 76ers (37-23) will square off. This matchup will be at Wells Fargo Center in Philadelphia, with Wednesday’s tip-off at 7:30 p.m. ET. Below, we look at the Knicks vs. 76ers odds and lines, and make our expert NBA picks, predictions and bets.

The Knicks were striggling before the All Star break and have lost the two games coming out of a break, falling to the Heat by 15 points and to the Sixers by 16. They’ve now lost nine of their last 10 games and covered the spread just once in that span. Though their defense has been solid (8th in  NBA in points allowed at 107), they’re the third-worst shooting team in the league with a field goal percentage of 43.4%.

The Sixers are trending in the opposite direction, winning their last two games by a total of 47 points – including that 16-point win over the Knicks on Sunday. G James Harden scored 27 and 29 points in his first two games with Philadelphia, already meshing well with his new team. The 76ers have won five of their last six games and are 4-1 ATS in their last five.

• Money line: Knicks +440 (bet $100 to win $440) | 76ers -650 (bet $650 to win $100)
• Against the spread (ATS): Knicks +10.5 (-112) | 76ers -10.5 (-108)
• Over/Under (O/U): 222.5 (O: -115 | U: -107)

Knicks at 76ers key injuries

Knicks

• SG Quentin Grimes (knee) out

76ers

• None