Oklahoma quarterback Spencer Rattler is the universal favorite to win the 2021 Heisman Trophy based on season-opening odds at regulated sportsbooks.

Rattler is +650 at BetMGM, ahead of Clemson quarterback DJ Uiagalelei, Alabama quarterback Bryce Young and Georgia quarterback JT Daniels. North Carolina quarterback Sam Howell and Ohio State quarterback C.J. Stroud are +1600 at BetMGM.

Rattler is +550 at PointsBet after tossing 28 touchdowns and completing 67.5 percent of his passes as a redshirt freshman in 2020. In 11 games, Rattler went 9-2 and rolled up 3,031 passing yards.

He’s vying to be the fifth Oklahoma quarterback since 2000 to win the award.