San Francisco Giants at San Diego Padres odds, picks and predictions

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The San Francisco Giants (69-64) and San Diego Padres (62-72) start a 4-game series at Petco Park Thursday. First pitch is slated for 9:40 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 3-3

The Giants hit the road for 7-games after finishing a 3-3 homestand. They held the Cincinnati Reds to a total of 6 runs in their 3-game series. San Francisco is 15-8 against everyone else in the NL West except the Padres. They have allowed nearly 7 runs per game (RPG) to San Diego.

The Padres allowed over 5 RPG over their 1-5 road trip. They have outscored San Francisco 41-30 in the 6 games played this season. San Diego is 35-33 at Petco Park this season.

Giants at Padres projected starters

TBD vs. RHP Pedro Avila

As of this publishing the Giants haven’t named their starting pitcher.

Avila (0-1 2.63 ERA) will make his 3rd start and 8th appearance. He has a 1.24 WHIP 3.6 BB/9 and 10.5 K/9 in 27 1/3 innings.

  • Last start: Loss 4 1/3 IP 5 ER 5 H 2 BB 4 K in 5-4 road loss at the Milwaukee Brewers Saturday
  • Only start vs Giants: Loss 4 IP 1 ER 4 H 3 BB 5 K in 3-0 road loss on Oct. 1 2021
  • 2023 home stats: 0-0 1.59 ERA (11 1/3 IP 2 ER) .214 OBA in 4 games

Giants at Padres odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub Lines last updated at 10:48 am. ET.

  • Moneyline (ML): Giants +105 (bet $105 to win $100) | Padres -125 (bet $125 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-190) | Padres -1.5 (+155)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

Giants at Padres picks and predictions


Padres 4 Giants 3


BET PADRES (-125).

This will be a get-right game for the Padres. They really struggled on their road trip but now they come home to the friendly confines of Petco Park against their division foe. The Giants haven’t named a starter which means it’ll likely be an opener situation/bullpen game. San Diego’s bats should handle any pitchers the Giants put out there.

Run line/Against the spread


I don’t like the run line at all in this one. I’m not confident enough in the Padres to cover that 1 1/2 and the odds are terrible if you take the Giants getting the 1 1/2. If you are going to bet just take the moneyline on the Padres.



I am just not solid on either side. I lean to the Under because of the recent play of both teams but without knowing the Giants pitcher at this point I’m going to avoid this bet.

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