MLB Game Preview: Los Angeles Angels at Seattle Mariners

Game Details:

  • Matchup: Los Angeles Angels vs. Seattle Mariners
  • Date: Thursday, September 11, 2025
  • Time: 9:40 PM EST
  • Venue: T-Mobile Park, Seattle, WA
  • Starting Pitchers: José Soriano (RHP) vs. Bryce Miller (RHP)
  • Moneyline Odds: Angels +129 | Mariners -158

The Setup

The Seattle Mariners host the Los Angeles Angels for a late-season divisional matchup at T-Mobile Park. The Mariners enter the contest as solid home favorites, looking to capitalize on their home-field advantage. Both teams have navigated seasons marked by significant injuries, and roster health could be a deciding factor in this September showdown.

Pitching Matchup

The Mariners will send right-hander Bryce Miller to the mound. While no current performance stats are available in the results, Miller was featured in a team injury update back in July, suggesting he has overcome a mid-season issue to take the ball for this important home start.

The visiting Angels will counter with their own righty, José Soriano. No specific information on Soriano’s recent performance was available in the search results, but he faces a tough task on the road against a favored opponent.

Team & Injury Analysis

Los Angeles Angels:The Angels come into this game as the underdogs, and recent injuries have not helped their cause. The most significant blow is the recent loss of catcher Logan O’Hoppe, who was placed on the 7-day concussion injured list on September 6th. Playing without their starting catcher will be a major challenge. Throughout the season, the Angels have also dealt with extended injury absences for key players like Yoán Moncada, Jorge Soler, and Chris Taylor, highlighting a year-long battle with roster depletion.

Seattle Mariners:The Mariners have persevered through their own share of injuries to get to this point in the season. Updates from throughout the summer show that players like outfielders Dominic Canzone and Luke Raley, infielder Ryan Bliss, and reliever Gregory Santos have all spent time on the injured list. While the potential return of some of these players by September has been noted, the team has had to rely on its depth all season long. Playing at home, where they have a record of at least 78 wins (per one result), gives them a clear edge.

Prediction

The key factors in this matchup point heavily in Seattle’s favor. The Mariners are playing at home, are the clear betting favorites at -158, and are facing an Angels team dealing with a very recent and impactful injury to starting catcher Logan O’Hoppe. While both clubs have injury lists, the loss of a starting catcher right before a series is a significant disadvantage for Los Angeles.

With Bryce Miller on the mound at T-Mobile Park, expect the Mariners to control the game and secure the win.

The Pick: Seattle Mariners Moneyline (-158)

Sources:
Los Angeles Angels Injury Status – ESPN
Angels injuries and roster moves
Los Angeles Angels Injury Status – ESPN (PH)
Mariners vs. Angels: Injury Report, Updates & Probable Starters …
Angels Injury Update: Kenley Jansen, Yoán Moncada
2025 Los Angeles Angels Injury Report | RosterResource …
Angels Injury Update: Soler and Taylor back to IL, Moore progressing
Angels Injury Report: Updates On Two Crucial Infielders
Angels Injury Report: Yoan Moncada Exits Game With Knee …
2024 MLB Games: Rays Angels Injury Report –

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