The Portland Trail Blazers (31-34) will play their 4th straight road game on Wednesday night when they visit the Boston Celtics (45-21), who have lost their last 3 games. Tip-off from TD Garden in Boston will be at 7:30 p.m. ET.

The Trail Blazers have won their last 2 games, beating the Orlando Magic  122-119 as 2.5-point underdogs and taking down the Detroit Pistons in a 6-point win as 5-point favorites. Those wins snapped a 3-game losing skid and pulled Portland closer to the .500 mark with the season winding down. The Blazers are 4-6 in their last 10, covering the spread 4 times.

The Celtics have sputtered of late, most recently losing a heartbreaking overtime game to the Cleveland Cavaliers 118-114 after F Grant Williams missed 2 free throws with the score tied and only 0.8 seconds left. It was their 3rd straight loss and the 2nd consecutive overtime defeat, although they did cover the spread against Cleveland as 7.5-point underdogs without F Jayson Tatum, C Robert Williams and PF Al Horford.

Trail Blazers at Celtics odds

• Moneyline (ML): Trail Blazers +380 (bet $100 to win $380) | Celtics -475 (bet $475 to win $100)
• Against the spread (ATS): Trail Blazers +9.5 (-105) | Celtics -9.5 (-115)
• Over/Under (O/U): 230.5 (O: -110 | U: -110)

Trail Blazers at Celtics key injuries

Trail Blazers

• PG Ryan Arcidiacono (back) out
• C Jusuf Nurkic (calf) questionable
• SG Anfernee Simons (ankle) out

Celtics

• SG Jaylen Brown (face) available
• PG Payton Pritchard (heel) questionable
• C Robert Williams III (hamstring) out

For most recent updates: Official NBA injury report.

Trail Blazers at Celtics picks and predictions

Prediction

Celtics 115, Trail Blazers 110

Moneyline

The Celtics are a better team than their 0-3 record reflects in the last 3 games, and they should have beaten the Cavs before the game went into overtime — they blew a 14-point 3rd-quarter lead. However, I’m not ready to bet on them to win outright just yet, especially at a number like -380 – even at home.

I would PASS on the money line.

Against the spread

Boston is 1-4 ATS in its last 5 games, 1 game worse than the Trail Blazers (2-3 ATS) in that same span. The problem is, the Celtics are huge favorites Wednesday and their last 3 wins outright have been by 4 points, 3 points and 4 points, covering the spread in just 1 of those games.

When the Celtics are favored by 7.5 points or more, they’re 16-15 ATS, while Portland is 3-4 when underdogs of 7.5-plus points, according to Covers BET TRAIL BLAZERS +9.5 (-105) with the points.

Over/Under

The total has gone Under in 2 of Portland’s last 3 games without Simons on the floor, leaving a clear void on offense. The Over is 7-3 in the Celtics’ last 10 games but they’ve also played 4 overtime games in that stretch, all of which went Over.

I like the UNDER 230.5 (-115) in this matchup with both teams playing their 3rd game in 4 days.