Game Details:
- Date: Tuesday, October 8th
- Time: 5:08 PM EST
- Venue: Wrigley Field, Chicago, IL
- Moneyline Odds: Brewers +101 | Cubs -123
An old National League Central rivalry is renewed as the Milwaukee Brewers travel to the friendly confines of Wrigley Field to take on the Chicago Cubs in a crucial October showdown. With the Cubs pegged as slight home favorites at -123, oddsmakers anticipate a tightly contested game. The Brewers, sitting at +101, present intriguing value as road underdogs.
Pitching Matchup
Milwaukee Brewers: Quinn Priester (RHP)
Chicago Cubs: Jameson Taillon (RHP)
This game features a duel between two right-handers. The Cubs will send veteran Jameson Taillon to the mound. Taillon will look to leverage his experience and the energy of the home crowd to shut down a competitive Brewers lineup.
Opposing him is Quinn Priester for the Brewers. Priester will be tasked with navigating a tough Cubs batting order in a high-pressure road environment. His performance will be key if the Brewers hope to pull off the upset.
Injury Report
Both teams are managing injuries as they head into this contest.
- Chicago Cubs: The Cubs have dealt with several key injuries. According to recent reports, pitcher Cade Horton was placed on the 15-day injured list with a right rib fracture and has no timetable for his return (Result 28). Other reports from 2025 noted that the team had previously managed injuries to outfielders Seiya Suzuki and Kyle Tucker (Results 4, 8), though another update suggested Suzuki had returned to the lineup by September 2025 (Result 9).
- Milwaukee Brewers: The Brewers have also been monitoring their roster’s health. Reports from September 2025 indicated potential concerns for pitcher José Quintana and a season-ending injury for reliever Shelby Miller, highlighting the depth challenges the team has faced (Results 24, 25).
Prediction
This matchup has all the makings of a classic divisional battle. The betting odds reflect just how close this game is expected to be. The Cubs are narrow favorites (-123), a line based heavily on Jameson Taillon’s veteran presence and the significant advantage of playing at Wrigley Field in October.
While the Brewers (+101) have the lineup to challenge anyone, the edge goes to the home team. Taillon’s ability to manage big moments, combined with the pressure of a road start for Priester, tilts the scales in Chicago’s favor. Expect a low-scoring, tense affair, but the Cubs should find a way to manufacture enough runs to secure a victory.
Prediction: Cubs 4, Brewers 2
Sources:
Brewers injuries and roster moves
Milwaukee Brewers Injury Status – ESPN
Milwaukee Brewers Injury Report and Status 2025 – CBSSports.com
Brewers Injury Update: Milwaukee At Risk Of Losing José Quintana
Brewers Injury Updates: Another Tommy John For Shelby Miller
Trevor MeGill update on his last bullpen? : r/Brewers
2025 Milwaukee Brewers Injury Updates – Live Reports and Player …
2025 MLB Games: Cubs Brewers Injury Report –
Latest Brewers injury update evokes worries of future roster crunch
2021 MLB Games: Pirates Brewers Injury Report –