Date: November 19

Time: 7:30 PM EST

Moneyline: Calgary Flames +136 | Buffalo Sabres -164

The Buffalo Sabres, listed as firm home favorites, will host the Calgary Flames in a cross-conference matchup. The Sabres are coming off a dramatic 5-4 overtime victory over Detroit on November 15 and will look to carry that momentum forward, though they will be doing so with a depleted blue line.

Buffalo Sabres Outlook

The Sabres enter this contest as the favorites (-164), but their defensive corps has taken a significant hit. Head Coach Lindy Ruff confirmed that defenseman Michael Kesselring will be out for “weeks” with a lower-body injury sustained in the win against Detroit and has been placed on injured reserve. His absence will be felt on the back end.

On a more positive note for Buffalo, the forward group may be getting some reinforcements. A report from November 10 stated that forward Jason Zucker was recovering from an illness and could return to action by the following weekend, making it likely he is available for this game. Additionally, forward Zach Benson is reportedly “getting closer” to a return and was expected to participate in Wednesday’s practice, putting his status for the game firmly in the “questionable” category.

Calgary Flames Outlook

The Flames come into Buffalo as the betting underdogs (+136), presenting potential value for bettors. Based on the available information, the Flames’ current injury status is clear. Unlike the Sabres, who have at least one key player confirmed out, there are no specific, recent injury reports listing any Calgary players as sidelined for this game.

With no major injuries reported in the provided results, the Flames may be entering this contest at or near full health. Facing a Sabres team with a confirmed injury to a key defenseman, Calgary will look to use its offensive depth to exploit the matchup and pull off the road upset.

Prediction

This game will likely be decided by whether the Flames’ offense can take advantage of a weakened Sabres defense. Buffalo is playing at home and is coming off an emotional win, which gives them a clear edge. However, the loss of Michael Kesselring is significant and cannot be overlooked.

While the Flames present good value as a +136 underdog, especially with their healthier roster, the Sabres are still the justified favorites at home. Buffalo has proven they can find ways to win, but their defensive vulnerability will likely keep this a close, high-scoring affair.

The Pick: Buffalo Sabres (-164). Expect the Sabres to feed off the home crowd and secure a victory, but the Flames will make them work for it.

Sources:
Calgary Flames Injury Report and Status 2025-26 – CBS Sports
Calgary Flames Injury Status – ESPN
Hurricanes vs. Flames Injury Report Today – March 2
2025-26 Injury Report – Calgary Flames
Predators vs. Flames Injury Report Today – January 4
Capitals vs. Flames Injury Report Today – January 28
Predators vs. Flames Injury Report Today – December 10
Predators vs. Flames Injury Report Today – November 15
Capitals vs. Flames Injury Report Today – February 25
Predators vs. Flames Injury Report Today – November 15