Game Details:
- Matchup: Seattle Seahawks (Away) at Arizona Cardinals (Home)
- Date: Wednesday, September 25th
- Time: 8:16 PM EST
- Venue: State Farm Stadium, Glendale, AZ
- Betting Odds: Seahawks -1.5, Total: 43.5
Game Preview
An NFC West rivalry is renewed under the lights as the Seattle Seahawks travel to Glendale to take on an Arizona Cardinals team reeling from a major injury. With a razor-thin point spread, oddsmakers expect a tight contest, but injuries to star running backs on both sidelines will be the dominant storyline.
The Seattle Seahawks enter this divisional showdown as slight road favorites, but their offensive game plan may be in flux. Running back Kenneth Walker has been dealing with an oblique injury that recently had him listed as doubtful for a game, and his status remains a significant concern. If Walker is limited or unable to play, Seattle’s “run the ball” philosophy will be tested, forcing more of the offensive burden onto the passing game.
For the Arizona Cardinals, the injury news is far more devastating. The team was dealt a season-altering blow with the news that star running back James Conner is out for the remainder of the year. Conner is the heart and soul of the Cardinals’ offense, and his absence will force a complete shift in their identity. The injury woes don’t stop there, as wide receiver Zay Jones is in the concussion protocol and key offensive lineman Will Hernandez is listed as questionable.
On a positive note for Arizona, tight end Trey McBride has cleared concussion protocol and is expected to play. He will likely become the focal point of the passing attack as the Cardinals try to manufacture offense without their primary weapon in the backfield.
Key Matchup
Cardinals’ Re-Tooled Offense vs. Seahawks’ Defense
Without James Conner, the Cardinals’ offense becomes more predictable. The Seahawks’ defense will likely focus its efforts on containing quarterback Kyler Murray and blanketing his top remaining target, Trey McBride. The question is whether Arizona’s backup running backs, like Emari Demercado, can be effective enough to keep the Seattle defense honest. If the Cardinals become one-dimensional, it could be a long night for their offense.
Prediction
This game is defined by which team can better withstand a significant injury to its starting running back. The loss of James Conner for the season is a catastrophic blow to the Cardinals, fundamentally changing their offensive capabilities. While the Seahawks are dealing with their own potential absence in Kenneth Walker, the impact of losing Conner feels more profound for Arizona.
With both offenses potentially missing their top rushers, points could be at a premium. The total of 43.5 seems to reflect this, and the under is a very strong possibility. The Cardinals will struggle to find an offensive rhythm without their workhorse, and the Seahawks are just talented enough on both sides of the ball to exploit that weakness, even on the road. Expect Seattle to do just enough to win and cover the small spread in a low-scoring divisional battle.
Prediction: Seahawks 20, Cardinals 17
The Pick: Seahawks -1.5
The Pick: Under 43.5
Sources:
Seahawks Injury Report | Seattle Seahawks – seahawks.com
Seattle Seahawks Injury Status – ESPN
Seahawks Injury Report : r/detroitlions
Kittle, Bosa and Williams Questionable for Week 11 vs. Seahawks …
[Brady Henderson] Seahawks injury report today: Bradford DNP with …
Cardinals-Seahawks injury report: James Conner out for year
Eagles vs. Seahawks Injury Report
Seattle Seahawks Injury Report and Status 2025-26 – CBSSports.com
Seahawks injury report: Kenneth Walker Doubtful, both LBs …
Thursday’s Saints vs. Seahawks injury report | Canal Street Chronicles