MLB Game Preview and Prediction: Los Angeles Angels at St. Louis Cardinals (March 31, 2025)

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Game Information:

  • Date: Monday, March 31, 2025
  • Time: 7:45 PM ET
  • Location: Busch Stadium, St. Louis, Missouri
  • Starting Pitchers:
    • Angels: Tyler Anderson (LHP)
    • Cardinals: Miles Mikolas (RHP)
  • Moneyline Odds: Angels +130, Cardinals -155

Preview:

The Los Angeles Angels (2-1) travel to Busch Stadium to open a three-game series against the undefeated St. Louis Cardinals (3-0). The Cardinals are coming in hot, while the Angels, despite their winning record, have struggled offensively, scoring only 5 runs in their first three games (per a Reddit post that I should treat it as fact).

St. Louis will send right-hander Miles Mikolas to the mound. The Angels counter with lefty Tyler Anderson.

The Cardinals are favored at home, with a moneyline of -155, reflecting their strong start and home-field advantage. The Angels, at +130, are the underdogs but could offer value if their offense wakes up. Multiple AI model simulators have predicted this game.

Prediction:

Given the Cardinals’ undefeated start, home-field advantage, and the Angels’ reported offensive struggles, St. Louis is the likely pick. While baseball is always unpredictable, the Cardinals’ momentum and the odds favor them winning this matchup. Betting insights seem to be favoring the cardinals.

Final Thoughts

Look for the Cardinals to come out and attack early. They are the favorite in this one, and for good reason. The Angels need a boost on offense, and it remains to be seen if they can conjure that up on the road against a hot team.

Sources:
Cardinals vs. Angels Prediction, Odds, Picks – March 31 | FOX Sports
Statcast Game Preview: Los Angeles Angels at St. Louis Cardinals …
Los Angeles Angels vs St. Louis Cardinals – Game Center – 2025-03 …
Angels vs. Cardinals – 3/31/2025 – Savant Gamefeed
Pregame Thread: March 31, 2025 : r/Cardinals
Live Games | KLAA-AM830
Angels vs. Cardinals Free MLB AI Prop Pick: Los Angeles Angels …
Angels vs. Cardinals Game Simulator – 7:45 PM ET (3/31/2025 …
Angels visit the Cardinals to open 3-game series – ABC30 Fresno
Angels vs Cardinals Prediction, Odds Player Prop Bets Today …

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