Every SEC team is in action Week 1, and there's no shortage of favorable lines. Let's dive in and examine the best SEC bets for Week 1.

College football fans received a look at Vanderbilt in Week 0, and the Commodores dominated in Hawaii. Now the rest of the SEC gets underway, beginning Thursday with Tennessee and Missouri playing in action at home. After a full slate on Saturday, including the season openers for preseason No. 1 Alabama and the defending national champion Georgia Bulldogs, LSU clashes with Florida State on Sunday to end the week.

There are a lot of enticing picks tied to SEC contests in Week 1, but finding the right ones to play is the key. Only one SEC school is an underdog this week, with Florida a 3-point dog against No. 7 Utah. That line shows just how much Vegas is respecting the SEC. An unranked team is just a field-goal underdog against a squad that should be contending for a College Football Playoff birth. 

Below, we look at the best SEC bets for Week 1 of the college football schedule (odds via DraftKings Sportsbook and BetMGM).

SEC Week 1 Top Picks

Ole Miss -22

Initially, it seems like Vegas is begging you to take the Trojans. When that happens, it’s best to take the other side. 

This will be the Rebels’ first look at USC transfer Jaxson Dart, and an experienced group of receivers is expected to help him significantly. The Ole Miss offense was great in 2021, while the defense struggled at times. Luckily for Ole Miss, the Trojans’ offense isn’t all that intimidating, and the Rebels should be able to simply outscore them.

Troy played teams very tough in 2021, including losing a road contest to South Carolina by just nine points. But the Ole Miss offense will be too much for the Trojans to handle.